Aging is Much of oxidative stress comes from the basic function of eating. As cells burn food, they also release toxic chemicals known as "free radicals" which cause cell damage and consequently -- oxidative stress. The level of oxidative stress is determined by the balance between the rate at which oxidative damage is induced (input) and the rate at which it is efficiently repaired and removed (output). The body fights back by making two anti-oxidant enzymes. But as people get older, those enzymes can get overwhelmed. To stop or slow the cells from getting overwhelmed by oxidative stress you need the proper nutrition plan and supplements. If you stick with most of the nutrition plans and bogus supplements today you will pretty much be on a treadmill to nowhere. The nutrition plan and supplements listed here have been researched over and over again with constant positive results. "A calorie-restricted diet provides all the nutrients necessary for a healthy life. A major factor in the age-related decline of bodily functions is the accumulation of 'oxidative damage' in the body's proteins, fats, and DNA. Oxidants - in particular, chemicals called 'free radicals' - are produced when food is converted to energy by cellular structures called mitochondria. One theory for how caloric restriction slows aging is that it lowers free-radical production by inducing the formation of efficient mitochondria. ... The induction of these efficient mitochondria in turn reduces oxidative damage in skeletal muscles. Consequently, this adaptive response to caloric restriction might have the potential to slow aging and increase longevity in humans as in other animals. ... CR and CR [plus exercise] both increased the number of mitochondria in skeletal muscle. Both interventions also reduced the amount of DNA damage - a marker of oxidative stress". Calorie Restriction Since the 1930's it has been known that a diet restricted in Calories, but otherwise rich in nutrients, dramatically extends the life span of experimental animals. Over two thousand studies have confirmed the effectiveness of Calorie restriction (or "under-nutrition without mal-nutrition) in a wide variety of species. While the effectiveness of this antiaging regimen is likely far greater than others currently available, the difficulty of the regimen for most people is also far greater. Serious life-extensionists should nevertheless consider trying at least a mild version of the diet. Two books we highly recommend are "Anti-Aging Plan" and "The Longevity Diet" Acetyl-L-Carnitine Research studies suggest that the vitamin-like nutrient L-carnitine may be able to slow down, or even reverse, brain deterioration. Experimental and clinical studies demonstrate that ALC may have a "significant capacity to slow, and even reverse, the effects of aging on the brain. At the University of California, Berkeley, an award-winning team of scientists has been conducting pre-clinical studies on aging. They discovered that by combining a natural, energy-boosting component (acetyl L-carnitine) with a powerful anti-oxidant (alpha lipoic acid) they could slow the cell aging process. Alpha Lipoic Acid (ALA) Alpha Lipoic Acid is a highly potent antioxidant that counteracts reactive free radicals in the mitochondria, the power plants of cells where energy for all cellular activities is generated. Some scientists believe that mitochondrial free radicals play an important role in human aging, and have theorized that extra amounts of free-radical inhibiting compounds such as lipoic acid may be able to help slow aging. Lipoic acid is also effective in recycling other antioxidants such as Vitamin E back into their original form after they detoxify free radicals. There also is evidence that lipoic acid can reduce glycation damage due to excess glucose in the blood, which may be involved in aging. Alpha Lipoic acid consists of two different forms (isomers) that have vastly different properties. The “R” form is the biologically active component (native to the body) that is responsible for lipoic acid’s phenomenal antioxidant effect. The “S” form is produced from chemical manufacture and is not very biologically active. Carnosine Carnosine is a multifunctional dipeptide made up of a chemical combination of the amino acids beta-alanine and L-histidine. It is found both in food and in the human body. Long- lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine. Muscle levels of carnosine correlate with the maximum life spans of animals. Carnosine levels decline with age. Muscle levels decline 63% from age 10 to age 70, which may account for the normal age-related decline in muscle mass and function. Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes. Aging causes irreversible damage to the body’s proteins. The underlying mechanism behind this damage is glycation. A simple definition of glycation is the cross- linking of proteins and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as unsightly wrinkled skin. Glycation is also an underlying cause of age-related catastrophes including the neurologic, vascular, and eye disorders. Carnosine is a unique dipeptide that interferes with the glycation process. Coenzyme Q10 Coenzyme Q10 (CoQ10) is an essential component of healthy mitochondrial function. It is incorporated into cells’ mitochondria throughout the body where it facilitates and regulates the oxidation of fats and sugars into energy. Aging humans have been found to have over 50% less CoQ10 on average compared to that of young adults. This finding makes CoQ10 one of the most important nutrients for people over 30 to supplement with. About 95% of cellular energy is produced in the mitochondria. The mitochondria are the cells “energy powerhouses” and many maladies have been referred to as “mitochondrial disorders.” A growing body of scientific research links a deficiency of CoQ10 to age-related mitochondrial disorders DHEA DHEA (dehydroepiandrosterone) is an adrenal hormone that is the precursor for steroid hormones such as testosterone and estrogen. DHEA declines precipitously with advancing age in both men and women. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book entitled DHEA and Aging. This book provided scientific validation for the many life extending effects of DHEA. Fish Oil Studies on omega-3 fatty acids are so impressive that an agency of the National Institutes of Health published a report stating that fish oil can help reduce deaths from heart disease. The FDA itself states supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may actually reduce the risk of coronary heart disease. There are several mechanisms attributed to fish oil’s beneficial effects. The latest government report cites the triglyceride-lowering effects of fish oil on reducing heart and blood vessel disorders. Another beneficial mechanism of fish oil is to protect healthy blood flow in arteries. Folic Acid, Vitamin B6 and Vitamin B12 Cardiovascular disease, the number-one killer of men and women, claims the lives of almost 40% of the more than 2.4 million Americans who die each year. Today, about 64 million Americans have some form of cardiovascular disease. Homocysteine a nonessential, sulfur-containing amino acid, is an independent marker of risk for the development of cardiovascular disease. Some researchers consider homocysteine as important a cardiovascular risk factor as low-density lipoprotein (LDL). Homocysteine can make blood clot more easily than normal, increasing the risk of both heart attack and death by heart attack. Inadequate levels of folic acid and vitamins B6 and B12 can lead to increased homocysteine levels. Green Tea Extract What makes green tea extract such an important nutrient are the large volumes of published scientific findings that validate its multiple biological benefits. The most significant findings involve studies showing that green tea extract helps maintain cellular DNA and membrane structural integrity. Decades of research shows that green tea inhibits the development of undesirable cell colonies. The active constituents in green tea are powerful antioxidants called polyphenols (catechins) and flavonols. Several catechins are present in green tea and account for the bulk of favorable research reports. Epigallocatechin gallate (EGCG) is the most powerful of these catechins. EGCG functions as an antioxidant that is about 25-100 times more potent than vitamins C and E. One cup of green tea may provide 10-40 mg of polyphenols and has antioxidant effects that are greater than a serving of broccoli, spinach, carrots, or strawberries. Theoretically, the high antioxidant activity of green tea makes it beneficial for protecting the body from oxidative damage due to free radicals. Melatonin Melatonin is a hormone produced by the pineal gland, which is located beneath the brain. Melatonin is a highly potent antioxidant, which has been described as the pacemaker of the aging clock in humans. It is released every night as part of our time-dependent biorhythms to help induce sleep and recuperation from fatigue. Published studies indicate the importance of maintaining youthful levels of melatonin to help protect against age-related degenerative diseases. Exercise Sorry, we had to mention the E-word. We put it last on our list because a few dieters would have been turned off by the thought of exercising to feel and look younger again. Without some form of exercise everything you are trying to accomplish when it come to your health and sometimes life would be a waste. Start off with some form of aerobic exercise like walking, biking, or swimming and if you really want to work up a sweat try an aerobics class. Now after a couple of weeks of getting the oxygen flowing through your veins it's time for some form of resistant exercise. You can use your own body weight, a weight machine, some barbells, or dumbbells to create this resistance. If you really want to get into a serious exercise program we recommend P90X. In 90 days P90X will bring you to a level of fitness that most people only dream of. The products and the claims made about specific products on or through this site have not been evaluated by The Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on AgeFormula.com or SaveLow.com is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. |
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